Scientists have determined how the SWI/SNF chromatin remodeling complex helps cancer cells 'remember' how to be cancerous after division. When a cell divides, it retains information about how to grow ...

Inactivation of SWI/SNF (switch/sucrose non-fermentable) chromatin remodeling complex subunits is a feature shared by select carcinomas and sarcomas with epithelioid morphology and variable keratin ...

A phase I/II study of ABT-888 in combination with 5-fluorouracil (5-FU) and oxaliplatin (Ox) in patients with metastatic pancreatic cancer (MPC). This is an ASCO Meeting Abstract from the 2013 ...

A phase IB study of the combination of selumetinib (AZD6244, ARRY-142886) and cyclosporin A (CsA) in patients with advanced solid tumors with an expansion cohort in metastatic colorectal cancer (mCRC) ...

Genetic mutations can lead to abnormal DNA transcription and, ultimately, cancer. Now, scientists at the University of Michigan have described a key nexus that several cancer-promoting genes depend on ...

The SWI/SNF complex is an essential chromatin remodeler that regulates DNA accessibility during brain development. Through combinatorial assembly of subunits encoded by paralogous genes, SWI/SNF ...

Recently, several chromatin remodeling complexes in yeast, Drosophila, and mammals have been shown to contain actin and actin-related proteins (arps). However, the function of actin in these complexes ...

In a recent article published in Nature Genetics, researchers showed that mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) chromatin remodeling complexes represent a potential class of ...

Scientists at St. Jude Children’s Research Hospital found that subunits of the SWI/SNF chromatin remodeling complex, which is mutated in 20% of all cancers, help cells maintain a memory of ...