All forms of life depend on enzymes—without them most biochemical reactions would proceed too slowly to sustain the processes of life. Enzymes function by binding to a compound known as a substrate.

Enzymes play a key role in cellular metabolic processes. To enable the quantitative assessment of these processes, researchers need to know the so-called “turnover number” (for short: k cat) of the ...

It is well known in physics and chemistry that equal charges repel each other, while opposite charges attract. It was long assumed that this principle also applies when enzymes -- the biological ...

Measuring Enzyme Kinetic Parameters with the ITC Universal Enzyme Assay Method Enzymes are important in drug discovery and development since they constitute approximately one-half of all known drug ...

Researchers at the Manchester Institute of Biotechnology (MIB) have demonstrated how genetically engineered enzymes can harness visible light to drive highly selective chemical reactions. This ...

All living things depend on millions of chemical reactions that happen constantly. Chemical reactions that keep you alive happen fast! When you eat food, breathe, play, and grow, all of these are ...

Researchers defined the structure of a substrate-bound iron 2-oxoglutarate (Fe/2OG) enzyme to explore whether these enzymes could be used to create a wide array of molecules. They saw that Fe/2OG ...

Reactions that can combine more than two molecular pieces in one go are a powerful way to build complexity quickly and save on costly isolation and purification. But the choreography for such a ...

Using directed evolution, researchers have developed an enzyme that catalyses the formation of biaryl bonds (Nature 2022, DOI: 10.1038/s41586-021-04365-7). This new enzyme makes carbon-carbon bonds ...