Frontiers

Artificial Intelligence and Protein Dynamics: Transforming Disease Modeling and Therapeutic Developments, Drug Discovery and Lead Optimization

Artificial intelligence (AI) is revolutionising the field of drug discovery and disease modelling, with a significant impact ...
eLife

A differentiable model for optimizing the genetic drivers of synaptogenesis

This study presents SynaptoGen, a differentiable extension of connectome models that links gene expression, protein-protein interaction probabilities, synaptic multiplicity, and synaptic weights, and ...
eLife

Translational reading frame determines the pathogenicity of C-terminal frameshift deletions in MeCP2: an alternative therapeutic approach

This study offers important insight into the pathogenic basis of intragenic frameshift deletions in the carboxy-terminal domain of MECP2, which account for some Rett syndrome cases, yet similar ...
Frontline

Gasping fish and new hope for Alzheimer’s

New studies suggest climate change accelerates river oxygen loss worldwide, while Alzheimer’s may be reversible via NAD+ ...