R-loops consist of double-stranded DNA-RNA hybrids and a complementary DNA strand that is displaced from the duplex. R-loops play important role in numerous normal physiological processes, including ...
Revolutions in gene therapy are rapidly changing the landscape of modern medicine. Revolutions in gene therapy are rapidly changing the landscape of modern medicine, forcing society and science alike ...
Some genetic disorders—such as cystic fibrosis, hemophilia, and Tay Sachs disease—involve multiple mutations across a person’s genome. The number and type of mutations can differ widely, even among ...
The centerpiece of the deal is the in vivo editor TSRA-196, which in preclinical studies has shown robust editing at SERPINA1, the locus linked to alpha-1 antitrypsin deficiency. Regeneron has forged ...
Regeneron Pharmaceuticals is putting more money into gene editing, announcing Monday a partnership with Tessera Therapeutics to develop an experimental program for a rare liver and lung disease. At ...
A new study describes a key molecular mechanism that explains how cells exchange information through extracellular vesicles (EVs), small particles with great therapeutic potential. The results, ...
Genome editing has been a long goal in molecular biology, medicine, and biotechnology, dating back to the discovery of restriction enzymes. However, the identification of zinc-finger nucleases (ZFN) ...
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