Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

Here are your top 49ers storylines for Wednesday, December 24th:

The San Francisco 49ers beat the Indianapolis Colts 48-27, led by Brock Purdy’s 5 TDs. Colin Cowherd asks if the now 11-4 49ers are serious title contenders.

The 49ers are coming off a win over the Titans following their bye week, their fourth consecutive win after a loss to the Rams had dropped them to 6-4 on the year. The playoff-bound Niners got another massive favor from the Seahawks on Thursday night, and they now control their own destiny in the race for the No. 1 seed in the NFC.

QB Brock Purdy rewards his offensive line with custom Rolex watches for Christmas as San Francisco pushes toward the NFC West title and NFL playoffs.

San Francisco (11-4) finishes the season with games at home against Chicago and Seattle. With wins in both of those, the 49ers would clinch home-field advantage in the NFC playoffs and would be two wins away from playing in the Super Bowl in their home stadium on Feb. 8.

Need to know. Brock off a bye. 49ers quarterback Brock Purdy has played two games off a bye in his career, and he has been nearly perfect in both. In those two g

Philip Rivers made sure to find 49ers linebacker Dee Winters after he sealed San Francisco's win with a pick-six off the Indianapolis Colts QB.