Kickoff from U.S. Bank Stadium in Minneapolis is set for 4:30 p.m. ET. The latest Vikings vs. Lions odds have Detroit favored by 7.5 points, while the over/under for total points scored is 43.5 via DraftKings Sportsbook. Before making any Lions vs. Vikings picks, check out the NFL predictions from the SportsLine Projection Model .

Our Lions vs. Vikings picks, odds & expert predictions expect Detroit to pick up a big win over Minnesota on Christmas Day, December 25.

Minnesota Vikings vs Detroit Lions picks, predictions, odds, win probabilities for NFL Week 17 Christmas Day game on Thursday, Dec. 25. Who will win?

The Vikings are turning to Max Brosmer to start Christmas Day against the Lions. Who is Minnesota's new starting quarterback against Detroit?

In this NFL mock draft, the Minnesota Vikings load up on defense, but potentially grab their future starting running back.

The Minnesota Vikings have activated running back and kick return specialist Ty Chandler off of injured reserve.

Minnesota Vikings star Justin Jefferson delivers a blunt assessment of the Detroit Lions defense ahead of their clash on Christmas Day.