Objective Inflammation plays crucial roles in the pathogenesis of several chronic inflammatory disorders, including Crohn's disease (CD) and UC, the two major forms of IBD. The urokinase plasminogen ...

Historically, inflammation against self was considered autoimmune, a concept that stems back to the seminal observations by Ehrlich, who described serum factors now known to be autoantibodies produced ...

Sanofi bought Dren’s DR-0201 program earlier this year for $600 million upfront and is running two Phase I trials in ...

Dren Bio retains the option to co-fund future development in exchange for U.S. co-promotion rights with Sanofi, a 50/50 share of U.S. profits and losses, and milestones plus t ...

The innate immune response constitutes the first line of defence against pathogenic microorganisms. Phagocytes, such as macrophages and neutrophils, engulf microorganisms into a vacuole or phagosome ...