Ben Sasse on How to Live While Dying

The former senator wants to heal the America he’s leaving behind.
eLife

Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

EM, biochemical, and cell-based assays to examine how Gβγ interacts with and potentiates PLCβ3. The authors present evidence for multiple Gβγ interaction surfaces and argue that Gβγ primarily enhances ...

Karpathy shares 'LLM Knowledge Base' architecture that bypasses RAG with an evolving markdown library maintained by AI

Karpathy proposes something simpler and more loosely, messily elegant than the typical enterprise solution of a vector ...