Kickoff from U.S. Bank Stadium in Minneapolis is set for 4:30 p.m. ET. The latest Vikings vs. Lions odds have Detroit favored by 7.5 points, while the over/under for total points scored is 43.5 via DraftKings Sportsbook. Before making any Lions vs. Vikings picks, check out the NFL predictions from the SportsLine Projection Model .

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The Lions had no major surprises on the initial injury report which means two straight games with no significant injuries. The team is now in the process of adding players with Kalif Raymond and Alex Anzalone who should be ready soon.

These teams met earlier this season on November 2 with the Vikings prevailing 27-24. McCarthy threw a couple of touchdown passes and the Vikings outgained the Lions on the ground, 142-65 to earn the win.