Effects of c-Myc overexpression on the DNA damage-induced G2/M checkpoint were studied in finite lifespan, normal human mammary epithelial cells (HMECs). Previously, we showed that c-Myc attenuates G1 ...

The c-Myc oncoprotein is frequently overexpressed in human cancers and is essential for cancer cell proliferation. The dysregulation of ubiquitin-proteasome-mediated degradation is one of the ...

Figure 1: INI1 interacts with c-MYC in the two-hybrid system. Figure 2: INI1 directly interacts with c-MYC in vitro. Figure 3: Co-immunoprecipitation of c-MYC with INI1. Figure 4: Dominant-negative ...

Preliminary safety and activity of perioperative triplet chemotherapy plus bevacizumab (bev) in patients with borderline resectable colorectal cancer liver metastases (CLM). Final phase II trial ...

Scientists at the Karolinska Institutet in Sweden have found a new region in the c-Myc oncogene that would allow the development of a binding compound to target it. Their discovery is based on a ...

Karen I. Zeller, XiaoDong Zhao, Charlie W. H. Lee, Kuo Ping Chiu, Fei Yao, Jason T. Yustein, Hong Sain Ooi, Yuriy L. Orlov, Atif Shahab, How Choong Yong, YuTao Fu ...

Herein, we demonstrate that MYC protein expression by IHC represents a rapid and inexpensive marker to identify MYC overexpression in DLBCL, including patients harboring MYC translocations, and that ...

The MYC oncogene family plays an important role in neoplastic disease, and has been extensively studied over decades. Evidence showing the N-terminal and C-terminal regions of MYC can function as a ...

So, what insight are we left with? “On the highest level,” notes Dr. Eisenman, “this study really demonstrates that a single amino acid substitution in a single protein is enough to predispose the ...

Cancer researchers have discovered surprising new functions for a protein called MYC, a powerful oncogene that is estimated to drive the development of almost half a million new cancer cases in the US ...