New ultra-detailed imaging exposes the hidden structure and behavior of chromatin condensates — and hints at how their failures may drive disease.

There is a huge amount of DNA in most human cells, and that DNA has to be carefully compacted and organized so that it will ...

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and ...

The nuclei of most human cells contains the entire genome, which would have a length of about six feet if it was fully extended. So this DNA has to be carefully compacted in cells, while still ...

This video shows how the length of linker DNA connecting the nucleosomes affects how the structures are arranged, which in turn affects the interactions between chromatin fibers and the network ...

Analyzing population-level chromatin accessibility data shows added benefit over utilizing only gene expression data in elucidating the genetic mechanism of disease-associated variants.

CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by ...

The developmental period is a critical window during which environmental cues interact with the genome to shape lifelong trajectories of health and disease.

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and ...

Inside every human cell, six feet of DNA folds into a nucleus that is only a few micrometers wide, yet still manages to ...