A new artificial intelligence-powered tool can help researchers determine how well an enzyme fits with a desired target, helping them find the best enzyme and substrate combination for applications ...

image: Enzyme substrate specificity involving material conversion processes is pertinent to e.g. biochemistry, metabolic engineering, and environmental remediation; however, it is one of the most ...

The Post group has worked to understand the basis of the catalytic power of enzymes using information from crystallography, kinetics, and a description of conformational distributions from molecular ...

The functionality, substrate specificity, and regiospecificity of enzymes typically evolve by the accumulation of mutations in the catalytic portion of the enzyme until new properties arise. However, ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 23 (Jun. 9, 2009), pp. 9215-9220 (6 pages) Altering the specificity of an enzyme requires precise ...

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental and translational research. The γ-secretase enzyme is capable of cleaving ...

Enzymes are the molecule factories in biological cells. However, which basic molecular building blocks they use to assemble target molecules is often unknown and difficult to measure. An international ...

Researchers have found a new enzyme, taken from Flavobacterium akiainvivens, that has a much broader specificity than the current leading alternatives. Subscribe to our newsletter for the latest ...