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Researchers identify chromatin accessibility changes driving stem cell transformation in MDS

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and ...

Chromatin accessibility maps reveal how stem cells drive myelodysplastic syndrome progression

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and ...
GMWatch

Gene editing disrupts multiple gene functions through large-scale epigenetic changes in a way that persists through successive cell generations

Study finds CRISPR/Cas gene editing causes “chromatin fatigue” – another surprise mechanism by which it can produce unwanted ...
EurekAlert!

BMI1s interact with condensin complexes to regulate chromatin 3D structure and gene expression in Arabidopsis

This study is led by Dr. Yue Zhou (State Key Laboratory of Gene Function and Modulation Research, School of Advanced Agricultural Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, ...
EurekAlert!

The current landscape of CRISPR-Cas9-based technologies for imaging of genomic loci in fixed and live cells

This includes the labeling of the dCas9 protein, engineering of sgRNA, and the use of dCas9 orthologs from different bacterial species. CRISPR, clustered regularly interspaced short palindromic ...