New ultra-detailed imaging exposes the hidden structure and behavior of chromatin condensates — and hints at how their failures may drive disease.

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and ...

There is a huge amount of DNA in most human cells, and that DNA has to be carefully compacted and organized so that it will ...

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and ...

A team of researchers has generated one of the most detailed 3D maps of human chromosomes, cataloging over 140,000 DNA looping interactions.

Study finds CRISPR/Cas gene editing causes “chromatin fatigue” – another surprise mechanism by which it can produce unwanted ...

This includes the labeling of the dCas9 protein, engineering of sgRNA, and the use of dCas9 orthologs from different bacterial species. CRISPR, clustered regularly interspaced short palindromic ...

Epigenetics plays a critical role in human health by regulating gene expression without the direct modification of DNA sequence. Aberrant epigenetic modifications mediated by changes in DNA and ...

Myelodysplastic syndrome (MDS) arises from defective blood stem cells that progressively lose their normal functions.