Get the opening NFL Week 17 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Dec. 25, 2025.

The Baltimore Ravens and Pittsburgh Steelers are set to battle for the AFC North crown, with the loser being eliminated from playoff contention. Meanwhile, the Carolina Panthers and Tampa Bay Buccaneers could also be thrown into a winner-take-all showdown for the NFC South.

A pair of NFC West rivals will clash on 'Thursday Night Football' when the Los Angeles Rams visit the Seattle Seahawks. Both teams are 11-3,

The stakes are high for several teams in the penultimate week of the NFL regular season. Here's how the odds see it going.

It all comes down to Week 18 in the NFC West and though the division title will come down to the Seahawks vs. 49ers matchup Saturday, the Rams aren't to be forgotten despite their Monday Night Football loss.

The Kansas City Chiefs are likely going to beat the Las Vegas Raiders on Sunday in the final game of the 2025 season. It’s a season everyone will like to quickly forget; however, at least they’re going out with a bang.

The Jacksonville Jaguars have revealed what uniforms they will be wearing for their Week 18 matchup with the Titans.