Jellyfish, sea sponges, amoebas and other animals on the early branches of the tree of life defy conventional aging. A new study reveals diversity of proteins called sirtuins in these animals compared ...

Mammals convert the energy stored in adipose (fat) tissue into heat via a process known as thermogenesis. This process is regulated by a family of signaling proteins called sirtuins. A recent study by ...

Study reveals that Sirtuin 7 regulates the functions of brown adipose tissue, thereby playing a critical role in overall energy regulation. Mammals convert the energy stored in adipose (fat) tissue ...

The Tong Lab's main goal is to elucidate the molecular mechanism of metabolic regulation in response to nutritional changes and aging. We study the role of the Sirtuin genes, especially SIRT2 and ...