Tobacco Control

Effectiveness of a school-based health education intervention on tobacco use intention among adolescents: a cluster-randomised controlled trial

Background Adolescence is a critical period for tobacco initiation, and intention to use tobacco strongly predicts uptake. In ...
The New England Journal of Medicine

Ivermectin to Control Malaria — A Cluster-Randomized Trial

Malaria control and elimination is threatened by the spread of insecticide resistance and behavioral adaptation of vectors. Whether mass administration of ivermectin, a broad-spectrum antiparasitic ...
Fierce Biotech

Small pools, big ideas: How the rare disease community is reimagining clinical trials

The traditional gold standard of clinical trials with a randomized, placebo-controlled design involving hundreds of patients ...
ascopubs.org

Efficacy and safety of trastuzumab deruxtecan for metastatic HER2+ and HER2-low breast cancer: A systematic review and meta-analysis of randomised controlled trials.

A randomized, double-blind, three-arm, parallel group, phase 1 study to assess the pharmacokinetics, safety, and tolerability of PERT-IJS following a single dose of 420 mg intravenous infusion ...

How a tiny circle of repeat offenders poisoned 100s of gold-standard medical trials for over a decade

Randomized Controlled Trials (RCTs) are the gold standard of medical research as random assignment approach helps eliminate ...
BMJ

Efficacy of cognitive functional therapy for pain intensity and disability in patients with non-specific chronic low back pain: a randomised sham-controlled trial

2 Postgraduate Program in Rehabilitation Sciences, Augusto Motta University Centre - UNISUAM, Rio de Janeiro, Brazil Objective This study investigated the efficacy of cognitive functional therapy (CFT ...