The fertilization of an egg by a sperm is central to human reproduction. A complex biological process transforms immature oocytes into ones that can be fertilized. The process begins in the female ...

Oocytes are immature egg cells that develop in almost all female mammals before birth. The propagation of future generations depends on this finite reserve of cells surviving for many years without ...

Mechanistic model for MTOC maturation in GV oocytes. The MTOC (grey) activates near the oocyte cortex, which requires recruitment of CKAP5 and TACC3. After activation, MTOC migrates to the nuclear ...

Nutritional status regulates energetically costly functions like reproduction. 1 Fat tissue serves as both an energy reserve and a metabolic sensor. This sensor operates through a series of ...

When sperm meets egg, the start of life is not quiet. Under a special microscope, researchers have watched a tiny light show at fertilization. They see a microscopic flash at fertilization, a burst of ...

A new review suggests CoQ10 could rejuvenate aging oocytes and enhance embryo quality, offering hope for women facing age-related fertility challenges while spotlighting the need for rigorous clinical ...

The accumulation of misfolded or damaged proteins in long-lived, non-dividing cells like neurons are linked to neurodegenerative diseases like Alzheimer's. A study now finds that the build-up of these ...