Merck has struck a deal to buy Calporta Therapeutics for up to $576 million. The takeover centers on TRPML1 agonists designed to treat neurodegenerative disorders by clearing toxic proteins from the ...

Scientists are revealing mroe about why TDP-43 has long been linked to the neurodegenerative disorders Alzheimer's, FTD, and ...

New research published in Brain, Behavior, and Immunity provides evidence that alcohol use disorder triggers a distinct type of immune response in the brain. The findings suggest that excessive ...

An editorial reviews evidence that periodontitis and oral bacteria may contribute to Alzheimer’s disease via ...

Progressive degeneration in a neuronal network: blue represents healthy neurons, while orange and red represent the protein NPTX2. Yellow shows the toxic aggregation of the protein TDP-43. Scientists ...

Experiments on an ultra-rare genetic mutation that causes neurodegeneration in children have helped uncover a new mechanism ...

In a new study published in Nature Metabolism titled “Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction,” researchers from the Buck ...

More than 40 Drosophila melanogaster genes have been discovered for which recessive, loss-of-function mutations cause adult onset degeneration of the central nervous system (CNS). A table presenting ...

A new study finds a correlation between neurodegeneration in obese people and Alzheimer's disease (AD) patients, suggesting that losing excess weight could slow cognitive decline in aging and lower ...

Heather Rice can recall a moment early in her career that helped shape how she thinks about Alzheimer’s disease. It happened when she was a zoology major at the University of Oklahoma in 2007, after ...

Some viral diseases could possibly contribute to neurodegeneration. Researchers found that certain viral molecules facilitated intercellular spreading of protein aggregates that are hallmarks of brain ...