Overall picks to win: 8-8 in Week 17 (173-82-1 for the season) Picks to win with 1-5 confidence: 4-7 (103-64-1) Picks to win with 6-10 confidence: 4-1 (70-18) Overall to cover the spread: 9-6-1 (130-117-9) Cover-the-spread picks with 1-5 confidence: 8-4-1 (107-93-8) Cover-the-spread picks with 6-10 confidence: 1-2 (23-23-1)

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 18 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

The final week of the 2025 NFL regular season is upon us, and if you’re still alive in a Survivor Pool, the SI Betting team is wishing you the best of luck. Wee

The top of the 2026 NFL Draft order, though still awaiting the results of Week 18, appears to be relatively set, with the Las Vegas Raiders likely to clinch that No. 1 overall pick by the end of the regular season.

Picking the entire NFL slate in the final two weeks of the season is really challenging. Who is playing? Where's the motivation? Which players have their minds on Cancun and Aruba?  Those are my excuses for having a terrible Week 17.

Week 18 is upon us in the NFL, and the conclusion of the 2025 regular season has many playoff scenarios, including the remaining two spots in the AFC and NFC.