The most important game of the weekend might actually occur in Las Vegas in a game that could have massive ramifications for the 2026 draft.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 17 on a 52-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

The 11-4 Chicago Bears are set to face the 11-4 San Francisco 49ers in what is set to be the matchup of the day. Fittingly, it could also be the most important fantasy football game of the week as well. With the championship on the line, everything could be settled by the end of the contest.

It’s not often that the two worst teams in the league square off this late in the season. So, the Las Vegas Raiders and New York Giants are set up for a big matchup in Week 17, as this game has appropriately been nicknamed ‘The Tank Bowl’!

Now, McClure has turned his attention to the Week 17 Sunday NFL DFS slate and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine .

The final week of the 2025 NFL regular season is here, and only two playoff spots remain. Week 18 will feature a pair of matchups that will determine the AFC North and NFC South. The AFC North battle between the Baltimore Ravens and Pittsburgh Steelers is a simple win-and-in situation,