PHILADELPHIA -- Every cell in the body has two genomes, one from the mother and one from the father. Until now, researchers have lacked the tools to examine -- in a single cell --the exact readout ...

April 23, 2010 — According to a study by scientists at Mount Sinai School of Medicine, New York City, genomic loss of imprinting (LOI) in cells of the human placenta is a continuing maturational ...

The conflict theory of genomic imprinting argues that parent-of-origin effects on allelic expression evolve as a consequence of conflict between maternally and paternally derived genomes. I derive ...

The conventional Mendelian model for diploid organisms assumes that the expression of an autosomal allele within an individual should be invariant of its sex of origin, that is, whether it is ...

Scientists at the University of Pennsylvania Perelman School of Medicine and the Children’s Hospital of Philadelphia (CHOP), have been able to examine a rare disease in which the maternal and paternal ...

For more than 20 years, DNA methylation has been the only known mechanism for regulating mammalian germline imprinting. Now, researchers at Harvard Medical School and Boston Children’s Hospital have ...

Arabidopsis seed development involves maternal small interfering RNAs (siRNAs) that induce RNA-directed DNA methylation (RdDM) through the NRPD1-mediated pathway. To investigate their biological ...

An analysis of rare genetic disorders in which children lack some genes from one parent suggests that maternal and paternal genes engage in a subtle tug-of-war well into childhood, and possibly as ...

Maternal gestational diabetes mellitus and excessive weight gain during pregnancy are associated with a significantly increased risk of childhood overweight and obesity, even in normal-weight ...