Stay up to date here with the latest news and highlights from the Indianapolis Colts' Week 16 matchup on Monday Night Football against the San Francisco 49ers.

It's always a terrific thing when the punter is never called upon. That is exactly what happened to the San Francisco 49ers in their 48-27 win against the India

USA TODAY's NFL experts make their picks for a Week 16 showdown between the Indianapolis Colts and San Francisco 49ers.

San Francisco cornerback Deommodore Lenoir was fined Saturday by the NFL after his unnecessary roughness penalty in Monday's 49ers win over the Colts.

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns, while George Kittle totaled seven receptions for 115 yards and a TD before leaving the game with an ankle injury.

In order for the Colts to come away with a much-needed win, here are three keys to accomplishing that. The Colts' downfield passing game against Seattle was almost nonexistent with Phillip Rivers at quarterback. He had just two pass attempts of 20-plus yards as the Colts prioritized getting the ball out of his hands quickly.

The 49ers dealt a devastating blow to the Colts' playoff hopes on Monday night and there was plenty of blame to go around in Indianapolis.

CB Deommodore Lenoir was fined $11,593 for unnecessary roughness (late hit) on Colts RB Jonathan Taylor. Here’s what happened.

A Sunday NFL Week 17 slate provides another chance to claim the latest DraftKings promo code, which gives new users $200 in bonus bets if your first $5 bet wins. One of the top games of the week features the Bills hosting the Eagles (+3) at 4:25 p.