Find single game tickets to the San Francisco 49ers vs. Indianapolis Colts NFL Week 16 matchup on Monday, December 22, 2025 at Lucas Oil Stadium.

On Sunday at 1 p.m. ET, Christian Kirk and the Houston Texans meet the Indianapolis Colts in Week 18. Game Time: 1 p.m. Kirk is not listed on the injury report this week. The Texans have no other receiver on the injury report. Kirk's 27 catches are good enough for 242 yards (24.2 per game) and one TD. He has been targeted on 50 occasions.

The San Francisco 49ers, with running back Brian Robinson Jr., will meet the Indianapolis Colts on Monday at 8:15 p.m. ET, in Week 16. Here are his stats -- 9 carries, 21 yards -- from his last game. Game Time: 8:15 p.m.

Having not played since Week 13 -- when his stats were: 0 receptions, 0 yards -- Luke Farrell and the San Francisco 49ers will meet the Indianapolis Colts in Week 16, on Monday at 8:15 p.m. ET. Game Time: 8:15 p.m.

The Seattle Seahawks vs. Indianapolis Colts game is set for 4:25 p.m. ET on Sunday, Dec. 14. The game will be played at Lumen Field in Seattle. Ticket prices start at $160. As the NFL regular season winds down, teams look to put their best foot forward ...

The Indianapolis Colts will host the San Francisco 49ers for Monday Night Football during Week 16. The game is scheduled for Monday, Dec. 22, at Lucas Oil Stadium in Indianapolis. Tickets to the matchup are available starting at $131. The Indianapolis ...

The Colts' Monday night loss to the 49ers is the Bills' gain. And the Jaguars'. And the Chargers'. All three teams have officially clinched playoff berths, as a result of the 49ers beating Indianapolis, 48-27.

So who has the advantage in key areas of this week's game? When looking at this week's matchup, as we know, the game is not played on paper. However, where these two teams rank in these key statistical areas could provide us with some valuable insight into where the Jaguars may have the upper hand in this game and also where they may not.