49ers vs Colts final score, results: Brock Purdy throws five touchdowns, 49ers control destiny after win vs. Colts originally ...

Quarterback Philip Rivers' shocking comeback to the NFL with the Colts could be over after the team lost their third-straight ...

The NFL season continues in Week 17 when the Indianapolis Colts host the Jacksonville Jaguars on Sunday. Start time, how to ...

NFL star quarterback Philip Rivers said he was finished playing in the NFL after a "three-week" blur with the Indianapolis ...

The Jacksonville Jaguars have moved within one victory of their first AFC South title since 2022. Trevor Lawrence ran for two ...

1:55 — The Colts take their second timeout of the half as their hopes of ending their five-game losing streak begins to fade.

The Houston Texans could clinch their first 12-win season under DeMeco Ryans with a victory over the Colts on Sunday at NRG Stadium.