Get the best 49ers vs. Colts predictions and odds ahead of Week 16 Monday Night Football on December 22, 2025. Take the Over.

SportsLine's model simulated Indianapolis vs. San Francisco on 'MNF' 10,000 times and reveals its NFL picks today

Here are the three most important games Colts fans should be locked into on Sunday, and why each result matters. At first glance, this game might feel less connected to Indianapolis, but it’s arguably just as important as the next two.

Brock Purdy and Philip Rivers go toe-to-toe in what should be an entertaining tilt at Lucas Oil Stadium this Monday night. Free 49ers vs. Colts SGP picks for December 22.

With an AFC South title potentially on the line, our expert NFL predictions & same-game parlay expect the high-flying Jaguars offense to keep its foot on the gas when they visit the Indianapolis Colts.

An NFL writer makes a bold claim about the helm of the Indianapolis Colts coaching staff ahead of the final week of the season.

The Jaguars have arguably the best kicker in the NFL since the bye week, especially after Cameron Dicker's stinker of a performance against the Texans on Saturday. Cam Little hasn't missed a kick since the Jaguars went to London two months ago, and he was once again a major factor on Sunday with three second-half field goals.

The Colts players addressed the team's six-game losing streak and getting eliminated from the playoffs after Sunday's loss to the Jaguars