San Francisco 49ers vs Carolina Panthers picks, predictions, odds, win probabilities for NFL Week 12 Monday Night Football game Nov. 24. Who will win?

"It’s turned a losing day for customers into a huge day for them. The third-highest-scoring game of the year, on prime time, is a New Year’s firework for the bettors," Caesars Sports vice president of trading Craig Mucklow said.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 18 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

NFL Week 18 betting spreads, lines, point totals for every game on NFL Week 18 schedule, with odds for favorites and underdogs in each NFL matchup.

CFP quarterfinals games are giving the NFL a run for its money when it comes to the betting action. Patrick Everson has insight on how the cash is coming in.

Here are the top betting storylines going into Week 18 of the NFL season, with all odds from BetMGM: How weird is the NFC South? The Buccaneers have lost seven of eight games and are still favored to beat the team in first place of the division. Tampa Bay is a 2.5-point favorite over the Panthers.

After coming into the season as Super Bowl contenders and heavily-favored playoff teams, the Lions and Ravens seasons are on life support. The pair are +1500 and +800, respectively, to make the postseason after suffering tough losses during Week 16.

The NFC West and the top overall seed in the conference is on the line Saturday at Levi’s Stadium when the San Francisco 49ers (12-4) host the Seattle Seahawks (13-3). Sam Darnold and the Seahawks have won six in a row to take a one game lead into the final game of the regular season.