Isaac Guerendo. He filled in nicely when both Christian McCaffrey and Jordan Mason were injured. It seemed like the S

The San Francisco 49ers' offense lost left tackle Trent Williams to a right hamstring injury on the first play of Sunday night's 42-38 victory over the Chicago Bears at Levi's Stadium, and the veteran lineman will have further testing Monday.

Kyle Shanahan's play-calling sheet was exposed during the broadcast of the 49ers-Bears game in prime time on Sunday.

The San Francisco 49ers have entered the chat as a serious Super Bowl contender this season. Anxious to end their 30-year drought without a championship, the 49ers are once again streaking at the right time under coach Kyle Shanahan coming out of Sunday night's thrilling 42-38 victory over the Chicago Bears .

Jac Collinsworth, Tony Dungy and Rodney Harrison discuss the NFL Coach of the Year race with Kyle Shanahan making a case along with Mike Vrabel, Liam Cohen and others.

Seattle presents many challenges, but one of the most difficult matchups is with wide receiver Jaxon Smith-Njigba, who isn’t a household name yet in his third year out of Ohio State but probably should be. The Seahawks felt good enough about him to trade D.K. Metcalf, their No. 1 receiver, to Pittsburgh in the offseason.

The 49ers have won six games in a row. And if they win just one more, they'll get the No. 1 seed and a first-round bye in the playoffs.

A few key 49ers players are dealing with injuries ahead of the team’s important Week 18 game against the Seattle Seahawks on Saturday at Levi’s Stadium. Most notably, left tackle Trent Williams, who suffered a hamstring injury on the first play of San Francisco’s 42-38 win over the Chicago Bears on Sunday.