With that, here are five storylines to watch for during the lead up to Bills (11-4) against the Eagles (10-5) in Week 17 at Highmark Stadium:

The defending Super Bowl champs, the Eagles have rebounded from a three-game losing streak to win their last two and, in the process, repeat as NFC East champions. Philly is the first team in the division to repeat since they did it back in 2004. It snapped the longest streak without a repeat champ by any division in NFL history.

The Philadelphia Eagles take on the Buffalo Bills on Sunday, Dec. 28, 2025. Here's how to watch pregame and postgame coverage on NBC10.

The Philadelphia Eagles enter their Week 17 matchup with the Buffalo Bills relatively healthy at this point in the season. The Bills have a long list of players on IR, as well as on their injury report this week. Here's the Eagles-Bills injury report, with analysis.

Sal Maiorana’s take: The Bills have two key advantages: they’re at home and the game matters more for their playoff hopes. Buffalo is 16-1 at home since early 2024, while the Eagles—already locked into at least the No. 3 NFC seed—are strong on the road (5-3). It’ll be tough, but Sal believes the Bills will pull it off.

Philadelphia Eagles wide receiver A.J. Brown did not practice on Wednesday after getting his wisdom teeth taken out.

This article originally appeared on Bills Wire: Bills vs. Eagles: Wednesday injury reports for both teams

The former Eagle, Poyer, led all Bills defenders in total tackles in Week 16 with 11. Bishop is the season leader with 83 in 15 games. Poyer has played five fewer games but ranks second (70). They have also combined for 2.5 sacks, five tackles for loss, 10 pass breakups, and four interceptions.

Cooper DeJean earned the NFC Defensive Player of the Week award after a standout performance against the Washington Commanders.

Bills QB Josh Allen did not practice on Tuesday as he injured his foot in the win over the Browns. On Wednesday, Allen returned to practice.

Philadelphia's fans are well aware of how good Dawkins is. He's a native of Rahway, New Jersey. He played for the Temple Owls. In 2016, his final season at the NCAA level, he earned First-Team All-AAC honors.