Following the Indianapolis Colts' performance on Monday Night Football, here are three takeaways from what took place against the 49ers.

It's been a brutal second half of the 2025 season for the Indianapolis Colts, but perhaps Christmas miracles are ahead.

Philip Rivers impressive play after a five-year hiatus has sparked conversations about the lack of young quarterback development.

The San Francisco 49ers still have a chance to claim the one seed in the NFC playoff bracket with a win in Week 16 over the Indianapolis Colts.

Two Indianapolis Colts players were named 2026 NFL Pro Bowlers. This will be running back Jonathan Taylor's third Pro Bowl and left guard Quenton Nelson's eighth Pro Bowl. Taylor has put together a very productive season. With two games to go in the regular season, he ranks second among all running backs in rushing yards with 1,489.

Jaguars vs. Colts bold predictions: Trevor Lawrence 300+ yards, Philip Rivers 2 INTs, Travis Etienne 110+ combined yards and 2 TDs.

Philip Rivers, the grandfather and former Pro Football Hall of Fame semifinalist, came out of retirement to play for the Indianapolis Colts.

Indianapolis Colts lose to the San Francisco 49ers and now are lost moving forward in the AFC South and AFC Conference.

The Indianapolis Colts, who want a victory from Santa Claus this Sunday, will face the Jacksonville Jaguars in their second regular-season meeting.